About the Program

In 2002, Bayer HealthCare instituted the Bayer Hemophilia Awards Program with the following mission:

The Bayer Hemophilia Awards Program supports basic and clinical research and education in hemophilia. Through grants provided to early career investigators, fellows in training, and other hemophilia care professionals, the program seeks to support the next steps for the next generation of care and treatment options for people with hemophilia worldwide.

Who We Are

The Bayer Group is a global enterprise with core competencies in the fields of health care, nutrition and high-tech materials. Bayer HealthCare, a subgroup of Bayer AG, with annual sales of EUR 16,913 million (2010), is one of the world’s leading, innovative companies in the health care and medical products industry and is based in Leverkusen, Germany. The company combines the global activities of the Animal Health, Consumer Care, Medical Care and Pharmaceuticals divisions. Bayer HealthCare’s aim is to discover and manufacture products that will improve human and animal health worldwide. Bayer HealthCare has a global workforce of 53,400 employees and is represented in more than 100 countries.

Bayer envisions the Hemophilia Awards Program as a step toward making the dream of hemophilia cures and improved treatments a reality.

The Bayer Hemophilia Awards Program demonstrates our commitment to the global bleeding disorders community and to advancing the state of the art of hemophilia care.

Research Priorities

Currently, the Program’s Research Priorities are focused on hemophilia. The program’s research priorities for the 2015/2016 cycle are as follows:

  • Patient-related, e.g. comorbidities, inhibitors, joint disease
  • Treatment-related, e.g. new products, regimens, gene therapy
  • Mechanistic, e.g. molecular mechanisms, experimental models
  • Outcomes research, e.g. patient-reported outcomes, quality of life

Previous Research

In previous award cycles the Program has provided funding to support several projects in the following areas:

  • Aspects of the molecular biology of vWF structure and function and the diagnosis and treatment of vWD
  • The function and regulation of platelets and the diagnosis of platelet disorders.

As a result, the Program will not award projects in these areas during this award cycle.

Excluded Research Topics

In order to maintain a focus on hemophilia and bleeding disorders, the Program will not support research focused on:

  • Products or technologies licensed or patented by competitors of Bayer
  • Cancer diagnosis or therapy
  • AIDS diagnosis or hepatitis therapy except where specifically related to patients with hemophilia and HIV, HCV or HBV
  • Cardiovascular disease diagnosis or therapy
  • Purely thrombotic disorders.

Dates & Deadlines

Thank you for your interest in applying for the Bayer Hemophilia Awards Program. This program represents Bayer’s continuing commitment to taking the next steps for the next generation of people with hemophilia to enjoy a better quality of life and treatment options.

Applications will be processed solely online and all applications must be submitted in English.

As a first step, applicants should submit a Letter of Intent (LOI) describing the proposed project in 500 words or fewer. People who submit LOIs will receive an email confirming receipt.

LOIs will be reviewed by all 14 members of the Grants Review and Awards Committee and, in some cases, additional information may be requested.

Selected applicants will be invited to submit a Full Proposal that will be reviewed by at least two members of the Grants Review and Awards Committee. These applicants will be emailed a Full Proposal application form.

The results of the review process and funding decisions for the 2017/2018 cycle will be communicated to applicants in April. Funded applicants must send a letter of acceptance and enter into an agreement outlining obligations and understandings prior to disbursement of funds.

Awardees will be invited to attend an Awards Dinner that will coincide with the biennial meetings of the World Federation of Hemophilia (WFH) or the International Society on Thrombosis and Haemostasis (ISTH).

The table below summarizes the application timelines for 2017/2018.

Action Date
LOI submissions Permitted throughout the year
Deadline for LOI consideration November 30,2017
GRAC reviews LOIs December 2017
GRAC informs applicants January 5, 2018
Applicants develop Full Proposals January/February 2018
Full Proposals submitted February 2018
GRAC reviews Full Proposals March 2018
Applicants notified of GRAC decisions April 2018
Funding available July/August 2018

GRAC, Grants Review and Awards Committee.

Application Process

Letters of Intent and Full Applications are reviewed by the Grants Review and Awards Committee which comprises 14 members, representing many of the leading experts from clinical and academic medicine:

  • Alok Srivastava MD, Vellore, India (chairman)
  • Valder Arruda MD, Philadelphia, USA
  • Marijke van den Berg MD, Utrecht, Netherlands
  • Kate Khair PhD, London, UK
  • Craig Kessler MD, Washington DC, USA
  • Riitta Lassila MD, Helsinki, Finland
  • David Lillicrap MD, Kingston, Canada
  • Pier Mannucci MD, Milan, Italy
  • Amit Nathwani MD, London, UK
  • Michael Nichol PhD, Los Angeles, CA, USA
  • Johannes Oldenburg MD, Bonn, Germany
  • Maria Santaella, MSN, Miami, FL, USA
  • Midori Shima MD, Nara, Japan
  • Gil White MD, Milwaukee, WI, USA

All members of the Grants Review and Awards Committee will review the Letters of Intent and determine which candidates will be invited to submit full applications. Full applications will be reviewed by at least two members of the committee.

Reviewers will evaluate full applications according to the criteria outlined in the Awards section of this website. The reviewers will provide written comments and preliminary numeric scores according to these criteria.

The Committee will meet to discuss individual proposals including strengths, weaknesses and scoring. In this meeting, a consensus score for each grant application will be agreed upon. Proposals will then be ranked according to these scores in order to determine funding. In the event of identical scoring, the Committee will discuss the proposals in question and revise the scoring in order to clearly define a ranked priority. Funding will occur on a regional basis.

Three regions are defined as:

  1. United States and Canada
  2. Europe (for the purposes of this award, the Europe region includes Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, United Kingdom)
  3. Japan, China, India, Australia and all other countries.

Awards will be determined on the final priority score as agreed by the Grants Review and Awards Committee. In the event that inadequate numbers of acceptable applications are received from a particular region, additional acceptable proposals will be funded solely on the basis of priority scores, without regard to region.

The Committee’s decision is final and there is no appeal mechanism. Applicants who have constructive suggestions about the review of their applications, or the process in general, are encouraged to contact us. See Contact.

Conflict of Interest

The Program has ‘conflict of interest’ guidelines that ensure reviews are conducted in a fair and equitable manner. Reviewers will not participate in the review or priority scoring of applications in which they, or institutions with which they are affiliated, have an interest. Also, to the extent practicable, reviewers will not participate in the review of proposals competing for funding with proposals for individuals associated with their institutions.

Confidentiality

The members of the Grants Review and Awards Committee are bound by the confidentiality rules generally applicable to such bodies.

Award Recipients: 2017

Fellowship Project Awardees

Doshi Dr Bhavya Doshi
Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Role of anti-BLyS directed therapy in inhibitor eradication
Toenges Dr Rosa Toenges
University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany
Exploring template-free CRISPR/Cas9 genomic editing for hemophilia A treatment

Early Career Investigator Awardees

Balestra Dr Dario Balestra
University of Ferrara, Ferrara, Italy
F8 splicing-switching molecules for tailored hemophilia A therapies
Basavaraj Dr Manjunath Goolyam Basavaraj
Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Novel strategies to enhance Factor X activation through improved Factor VIIIa cofactor activity and stability
Lee Dr Adrienne Lee
University of Calgary, Calgary, AB, Canada
The role of factor VIII and joint arthropathy in bone density, microarchitecture and bone strength in adolescent severe hemophilia A
Pavani Dr Giulia Pavani
French National Institute of Health and Medical Research, Paris, France
Targeted integration of FVIII in the globin locus for ex vivo gene therapy of hemophilia A
Singer Dr Heike Singer
Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
Intracellular identification of FVIII from HA-patients with nonsense mutations in relation to their MHC-driven risk for inhibitor formation

Special Project Awardees

Margaritis Dr Paris Margaritis
Children’s Hospital of Philadelphia, Philadelphia, PA, USA
The effects of the EPCR–factor VII/VIIa interaction in normal and hemophilic conditions
Preston Dr Roger Preston
Royal College of Surgeons in Ireland, Dublin, Ireland
Engineered thrombomodulin variants as novel pro-haemostatic agents for haemophilia therapy
Toh Professor Cheng Hock Toh
University of Liverpool, Liverpool, UK
Histone-enhanced prothrombin activation: Unravelling the mechanism for new therapies in hemophilia
Zhang Dr Ai-Hong Zhang
Uniformed Services University of the Health Sciences, Bethesda, MD, USA
BAR regulatory T cell therapy for anti-FVIII inhibitor development

Caregiver Awardees

Sulochana Ms. Sulochana Badagabettu
Manipal College of Nursing, Manipal, India
Explore the bio-psychosocial status (physical symptoms, self-reported anxiety, stress and social support), coping strategies and lived experiences among women carrier for haemophilia: A mixed method approach
Joseph Ms. Cilla Joseph
Hemophilia Treatment Center, District Hospital, Aluva, India
Effectiveness of hydrotherapy along with Ai Chi techniques for arthritic knee joint in hemophilia patients
McCabe Ms. Erin McCabe
Governors of the University of Alberta, Edmonton, AB, Canada
The assessment of therapeutic relationships in hemophilia care

Outcomes Research Awardees

Mancuso Dr Maria Elisa Mancuso
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy
A prospective registry target on critical outcomes in older patients with severe/moderate hemophilia
Resseguier Dr Noémie Resseguier
Assistance Publique Hopitaux de Marseille, Marseille, France
Quality of life and adjustment among siblings of children and adolescents with severe hemophilia

Past Award Recipients